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Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on

Zhen Zhang, Na Jiang, Zhaohui Ni

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 349-358 doi: 10.1007/s11684-017-0571-2

Abstract: morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosisInflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis.This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key

Keywords： peritoneal dialysis     peritoneal fibrosis     inflammation     angiogenesis    

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Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 100-107 doi: 10.1007/s11684-009-0013-x

Abstract: The aim of this study was to explore the expression of integrin-β1 in different stages of hepatic fibrosisand intervention of resveratrol as well as the way by which integrin-β1 promoted hepatic fibrosis.Hepatic fibrosis models of male Sprague Dawley (SD) rats were created and intragastric administrationLiver function and pathological sections of each group in different stages of hepatic fibrosis was testedas the development of hepatic fibrosis.

Keywords： liver fibrosis     integrin-β1     resveratrol     tumor growth factor-β     tissue inhibitor of metalloproteinase-1    

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Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failureThe purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis.We assessed cardiac fibrosis and pathology in mice subjected to transverse aortic constriction (TAC).In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiacSildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiac

Keywords： PDE5     cardiac fibrosis     TGF-β     CREB    

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Curbing the burden of lung cancer

Alexandra Urman,H. Dean Hosgood

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 228-232 doi: 10.1007/s11684-016-0447-x

Abstract:

Lung cancer contributes substantially to the global burden of disease and healthcare costs.Focusing on prevention is an important factor to reduce the burden of screening, treatment, and lungThe International Agency for Research on Cancer has identified several lung carcinogens, which we believeTo curb the societal burden of lung cancer, healthcare resources need to be focused on early detectionlung cancer.

Keywords： lung cancer     screening     risk factors     environmental    

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Clinical characterization and diagnosis of cystic fibrosis through exome sequencing in Chinese infants

Liru Qiu, Fengjie Yang, Yonghua He, Huiqing Yuan, Jianhua Zhou

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 550-558 doi: 10.1007/s11684-017-0567-y

Abstract:

Cystic fibrosis (CF) is a fatal autosomal-recessive disease caused by mutations in the CF transmembrane

Keywords： cystic fibrosis     pseudo-Bartter syndrome     hypokalemic alkalosis     CFTR gene     mutations     infants     diagnosis    

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FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 714-728 doi: 10.1007/s11684-022-0959-5

Abstract: Here, we demonstrate the involvement of FRMD6 in lung cancer progression.We find that FRMD6 is overexpressed in lung cancer tissues relative to in normal lung tissues.In addition, the enhanced expression of FRMD6 is associated with poor outcomes in patients with lungsquamous cell carcinoma (n = 75, P = 0.0054) and lung adenocarcinoma (n = 94, lung cancer progression by activating the mTOR

Keywords： FRMD6     lung cancer     mTOR pathway    

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Pathogenesis sequences in Gejiu miners with lung cancer: an introduction

Li Bian,Yonghua Ruan,Liju Ma,Hairong Hua,Li Zhou,Xiaoyu Tuo,Zheyan Zhou,Ting Li,Shiyue Liu,Kewei Jin

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 344-349 doi: 10.1007/s11684-015-0399-6

Abstract:

Tin miners in Gejiu, Yunnan Province, China are at high risk of developing lung cancer with significantpresented pathological characteristics, such as fibroplasia in carcinomas, peri-cancerous tissue in lungOur findings suggested that pulmonary fibrosis may increase the risk and promote the occurrence of lungcancer, which can lead to lung fiber hyperplasia.

Keywords： Yunnan tin mine     miners     lung cancer    

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The epidemic status and risk factors of lung cancer in Xuanwei City, Yunnan Province, China

Yize Xiao, Ying Shao, Xianjun Yu, Guangbiao Zhou

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 388-394 doi: 10.1007/s11684-012-0233-3

Abstract: Unfortunately, the lung cancer morbidity and mortality rates in this region are among China’s highestIn 2004–2005, the crude death rate of lung cancer was 91.3 per 100 000 in the whole Xuanwei CityThe epidemiologic distribution (clustering patterns by population, time, and space) of lung cancer inThe main factor that associates with a high rate of lung cancer incidence was found to be indoor airTaken together, lung cancer in this smoky coal combustion region is a unique model for environmental

Keywords： lung cancer     Xuanwei     smoky coal combustion     polycyclic aromatic hydrocarbons     epidemiology    

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Molecular markers and pathogenically targeted therapy in non-small cell lung cancer

Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 245-255 doi: 10.1007/s11684-009-0044-3

Abstract: Lung cancer is one of the most common human cancers and the number one cancer killer in the United StatesIn general, lung cancer includes small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), but NSCLC accounts for approximately 90% of lung cancer.tools, which can improve current early detection to reduce mortality from lung cancer, do not exist.These molecular markers in NSCLC demonstrated close associations with the development of lung cancer

Keywords： lung cancer     carcinoma     non-small cell lung cancer     molecular markers     targeted therapy    

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MicroRNAs and lung cancers: from pathogenesis to clinical implications

Ji Qi, David Mu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 134-155 doi: 10.1007/s11684-012-0188-4

Abstract:

Lung cancer is the leading cause of cancer-related deaths in the US and worldwide.functions of small-RNA-based, posttranscriptional gene regulators, i.e. microRNAs, in the pathogenesis of lungmicroRNAs as markers for diagnosis, prognosis and the promising field of microRNA-based novel therapies for lung

Keywords： lung biology     lung cancer     microRNA    

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Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 760-765 doi: 10.1007/s11684-021-0899-5

Abstract: To elaborate the outcomes of patients awaiting lung transplantation (LTx) after the implementation ofafter brain death, we performed a retrospective study that encompassed 205 patients with end-stage lungInterstitial lung disease (ILD) (103/180, 57.2%) and chronic obstructive pulmonary disease (COPD) (56

Keywords： lung transplantation     donation after brain death     waitlist    

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Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin

ZHANG Xiaomei, JIANG Liangduo, ZHANG Wei, WU Jianjun, LU Xiangfeng

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 314-316 doi: 10.1007/s11684-008-0060-8

Abstract: The aim of this paper is to observe the effect of the Feixian Recipe on pulmonary fibrosis in rats.A rat model with pulmonary fibrosis was established by intratracheal injection of bleomycin.On days 14, 28 and 45, the contents of laminin, collagen I and collagen III in lung tissue homogenateFeixian Recipe has a significant therapeutic effect on bleomycin-induced pulmonary fibrosis in rats.

Keywords： bleomycin     intratracheal injection     prednisone     collagen     bleomycin-induced pulmonary    

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Diffuse cystic lung diseases

Jay H. Ryu, Xinlun Tian, Misbah Baqir, Kaifeng Xu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 316-327 doi: 10.1007/s11684-013-0269-z

Abstract:

Diffuse cystic lung diseases are uncommon but can present a diagnostic challenge because increasingCyst in the lung is defined as a round parenchymal lucency with a well-defined thin wall (<2 mm thickness“Diffuse” distribution in the lung implies involvement of all lobes.associated with advanced fibrosis, and several other rare causes including metastatic disease.High-resolution computed tomography of the chest helps define morphologic features of the lung lesions

Keywords： cyst     lung disease     interstitial lung disease     lymphangioleiomyomatosis     Langerhans’ cell histiocytosis     Birt-Hogg-Dubé    

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Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice

CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 154-165 doi: 10.1007/s11684-008-0029-7

Abstract: In order to investigate the effect of paeoniflorin (PAE) on hepatic fibrosis of mice with and , a modelof hepatic fibrosis caused by schistosomiasis was established in mice infected with cercariae of .Hepatic granuloma and fibrosis were evaluated via HE and Masson staining. The expression of ?significantly reduce the concentration of serum HA, the size of egg granuloma, the severity of hepatic fibrosisIn a word, PAE can prevent hepatic granuloma and fibrosis caused by schistosomiasis japonica through

Keywords： cercariae     collagen     hyaluronic     OPMCM     soluble    

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Clinical factors associated with composition of lung microbiota and important taxa predicting clinical

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 389-402 doi: 10.1007/s11684-021-0856-3

Abstract: Few studies have described the key features and prognostic roles of lung microbiota in patients withvariance found that positive bacteria lab test results had the strongest independent association with lungThe positive bacteria lab test results, AKI, and plasma MIP-1β level were associated with patients’ lung

Keywords： severe community-acquired pneumonia     lung microbiota     clinical improvements     7-category ordinal scale    

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Title Author Date Type Operation

Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on

Zhen Zhang, Na Jiang, Zhaohui Ni

Journal Article

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Journal Article

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

Curbing the burden of lung cancer

Alexandra Urman,H. Dean Hosgood

Journal Article

Clinical characterization and diagnosis of cystic fibrosis through exome sequencing in Chinese infants

Liru Qiu, Fengjie Yang, Yonghua He, Huiqing Yuan, Jianhua Zhou

Journal Article

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Journal Article

Pathogenesis sequences in Gejiu miners with lung cancer: an introduction

Li Bian,Yonghua Ruan,Liju Ma,Hairong Hua,Li Zhou,Xiaoyu Tuo,Zheyan Zhou,Ting Li,Shiyue Liu,Kewei Jin

Journal Article

The epidemic status and risk factors of lung cancer in Xuanwei City, Yunnan Province, China

Yize Xiao, Ying Shao, Xianjun Yu, Guangbiao Zhou

Journal Article

Molecular markers and pathogenically targeted therapy in non-small cell lung cancer

Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD

Journal Article

MicroRNAs and lung cancers: from pathogenesis to clinical implications

Ji Qi, David Mu

Journal Article

Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death

Journal Article

Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin

ZHANG Xiaomei, JIANG Liangduo, ZHANG Wei, WU Jianjun, LU Xiangfeng

Journal Article

Diffuse cystic lung diseases

Jay H. Ryu, Xinlun Tian, Misbah Baqir, Kaifeng Xu

Journal Article

Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice

CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang

Journal Article

Clinical factors associated with composition of lung microbiota and important taxa predicting clinical

Journal Article